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Abstract: Uniformly, molecularly imprinted polymeric microspheres (EM-MIPMs) were prepared by emulsion polymerization using erythromycin as template molecule, methacrylic acid (MAA) as functional monomer, ethylene glycol dimethacrylate (EDMA) and sodium dodecylbenzenesulfonate (SBS) as cross-linker respectively and emulsifier respectively. Characterization of the obtained erythromycin-MAA complexes was achieved by ultraviolet (UV) absorption spectroscopy, fourier transform infrared (FT-IR) spectroscopy and nuclear magnetic resonance (1H NMR) spectroscopy. The results showed that erythromycin-MAA complexes were obtained by cooperative hydrogen bonding interaction. Surface features and thermal stability of EM-MIPMs were investigated by scanning electron microscope (SEM) and thermal gravimetric analyzer (TGA). The EM-MIPMs were uniformly microspheres and the average diameter of EM-MIPMs was 4.24 μm were larger than those of the non-imprinted polymeric microspheres, and it exhibited outstanding thermal stability. Kinetic, equilibrium adsorption and selectivity adsorption experiments (solid-phase extraction) were adopted to study the binding properties and molecule recognition character of EM-MIPMs for erythromycin. Kinetic experimental data were well-described by the pseudo-second-order kinetic model. The binding of erythromycin was analyzed by Langmuir and Freundlich isotherm models. The EM-MIPMs suggested outstanding affinity toward erythromycin, equilibrium experimental data of EM-MIPMs fitted the Langmuir isotherm well, the binding amounts reached to 0.242 mmol g-1. Meanwhile, solid-phase extraction experiments demonstrated that EM-MIPMs displayed high affinity to target molecules over competitive RM and EEs (roxithromycin and erythromycin ethylsuccinate).
Template and target information: erythromycin
Author keywords: Erythromycin, molecularly imprinted, microsphere, adsorption, binding property, recognition property