Inventors: Mashelkar RA, Kulkarni MG, Karmalkar RN
Patent Title: Polymer composition for controlled release of active ingredients in response to pH, and a process of preparing the same
Publication date: 1998
Publication number: US5,851,546

Abstract: The present invention provides a polymer for the controlled release of a pendent chain linked active ingredient, and a process for the preparation of such a polymer for the controlled release of an active ingredient in response to pH. The process involves selecting a vinyl monomer to which the active ingredient molecule is covalently linked through a pendent group, and selecting monomers bearing catalytic groups. The active ingredient-bearing monomer and the catalytic group-containing monomer are brought in juxtaposition either by complexation or molecular imprinting, and then polymerized with a hydrophilic monomer and crosslinker under an inert atmosphere with a suitable polymerization initiator.
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