Inventors: Mosbach K, Kriz D, Ansell RJ
Patent Title: Preparation and use of magnetically susceptible polymer particles
Publication date: 2001
Publication number: US6,316,235

Abstract: Polymer particles are formed containing molecular memory recognition sites and magnetically susceptible components. The particles are prepared by co-polymerizing one or more monomers and a cross-linking agent in the presence of at least one imprint molecule and at least one magnetically susceptible component such as iron oxide or nickel oxide, and removing the imprint molecule to form molecular memory recognition sites. The particles are also prepared by co-polymerizing the monomer and cross-linking agent in the presence of the imprint molecule to produce particles, removing the imprint molecule and associating magnetically susceptible components with the particles. The particles may also be prepared containing selective adsorbents such as cells or antibodies. The particles are used for selective adsorption of a product such as separating and resolving two different enantiomeric forms due to one of the forms adsorbing to a memory recognition site created by using the form as an imprint molecule. A magnetic field is used to separate particles containing an adsorbed product from a solution in which the product is adsorbed to the particles.
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