Inventors: Haginaka A
, Sanpei H
Separating agent, separation of estrogen compound and estrogenic substance, and screening, adsorbing and removing of estrogenic substance
Publication date: 2000
PROBLEM TO BE SOLVED: To separate estrogen compounds and estrogenic substances by reverse phase high-performance liquid chromatography by introducing a template structure to the estrogen compounds and estrogenic substances into polymer particles.
SOLUTION: Estrogen compounds and/or estrogenic substances are mixed with a polymerizable monomer this monomer is polymerized and the estrogen compounds and/or estrogenic substances are removed to introduce a template structure into polymer particles. In other way, estrogen compounds and/or estrogenic substances are mixed with a linear polymer, this polymer is allowed to react with a crosslinker to form a crosslinked polymer and the estrogen compounds and/or estrogenic substances are removed. The polymer particles may be produced by seed polymerization. When the polymerizable monomer is polymerized, a multifunctional polymerizable monomer is preferably used to form a crosslinked structure.
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