Inventors: Thaysen J
, Hegner A
Stress sensor with capture coating for detecting a target substance
Publication date: 2005
The invention relates to a stress sensor for detecting a target substance in a fluid comprising one or more sensor units e.g. shaped as cantilevers and comprising a capture coating and a detecting system. The invention also relates to a method of generating a capture coating for a target substance onto a sensor unit. The object of the present invention is to provide a stress sensor with an improved selectivity compared with prior art stress sensors. Another object is to provide a stress sensor which is relatively simple and cheap to produce, and which can be produced with high uniformity. The problem is solved in that the capture coating comprises a molecular imprinted polymerizate (MIP) for the target substance. This has the advantage of providing improved stability and robustness compared to for example antibodies. The MIPs can be stored at room temperature and withstand treatment with strong acid or base and can be reused a great number of times without any significant loss in affinity and selectivity. The invention may e.g. be used for implementing very sensitive mechanical stress sensors, e.g. in the form of micro cantilevers for detection of molecular interaction.
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