Inventors: Talebpour S
, Leonard SW
, Emadi-Konjin P
Immunoassays with enhanced selectivity
Publication date: 2006
The present invention provides a method for the detection of an analyte in a specimen comprising two steps. First, the specimen is contacted with a substrate having receptors bound thereon, having higher affinity for cross-reactive substances than for the analyte, in order to increase the ratio of the analyte to the cross-reactive substances. Then, the treated specimen is assayed by using another receptor while decreasing the effects of the cross-reactive substance contained in the original specimen. The receptors in the first step are preferably molecular imprinted polymers that are capable of absorbing multiple cross-reactive substances.
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