Inventors: Redmond G, Kewell A, Kruger J, Von Papen G
Patent Title: An analysis system
Publication date: 2009
Publication number: WO/2009/034563

Abstract: An analysis system comprises a sampling cartridge (11) comprising a housing (21, 22) having an inlet (23) for receiving a fluid sample, a sensor (26, 45), and a guide (40, 42) extending between the inlet and the sensor for guiding sample into contact with the sensor. The system also has an optical detection reader (13) for optically inspecting the sensor. The cartridge housing has an inspection window (34) and the reader (13) comprises a socket to receive the cartridge (11), and an optical system (1183, 1186) for inspecting the sensor through the window. The cartridge comprises parallel microfluidic channel (42) for flow of sample from the inlet into contact with the sensor. The sensor comprises discrete sensor pads (45) in at least one channel, with an antibody, an antigen, or molecular imprinted polymer. The channels are of microfluidic size, having a cross-sectional area in the range of about 0.3 mm2 to about 5 mm2. At least one channel comprises a reagent pad (43) upstream of the sensor (45). The inlet of ihe cartridge comprises an extraction chamber (23) communicating with a draining chamber having a top reservoir (61) and a bottom reservoir (63), in turn communicating with a distribution chamber (40). Together, these chambers and the interfaces between them guide sample flow in a uniform manner between the channels and also remove impurity particles and bubbles.
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