Inventors: Gong GL, Chen S, Li H, Wang N
Patent Title: Fermentation production method of Epothilone D provided with molecular imprinting polymer
Publication date: 2012
Publication number: CN102373251

Abstract: The invention discloses a fermentation production method of Epothilone D provided with a molecular imprinting polymer. The special molecular imprinting polymer adsorbing the Epothilone D is added in the fermentation production process of the Epothilone D, so the Epothilone D produced in fermentation is continuously adsorbed by the molecular imprinting polymer before reaching absorption balance in fermentation, and on the other hand, the Epothilone D is adsorbed by the molecular imprinting polymer, which is conductive to the separation of the Epothilone D in a fermentation product. The Epothilone D can be separated from fermentation liquor as long as the molecular imprinting polymer used as sediment is centrifugally separated and collected, then the Epothilone D is extracted from the molecular imprinting polymer, and the molecular imprinting polymer can be reused after being dried.
URL: http://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120314&DB=EPODOC&locale=en_EP&CC=CN&NR=102373251A&KC=A&ND=1