Inventors: Gong GL
, Chen S
, Li H
, Wang N
Fermentation production method of Epothilone D provided with molecular imprinting polymer
Publication date: 2012
The invention discloses a fermentation production method of Epothilone D provided with a molecular imprinting polymer. The special molecular imprinting polymer adsorbing the Epothilone D is added in the fermentation production process of the Epothilone D, so the Epothilone D produced in fermentation is continuously adsorbed by the molecular imprinting polymer before reaching absorption balance in fermentation, and on the other hand, the Epothilone D is adsorbed by the molecular imprinting polymer, which is conductive to the separation of the Epothilone D in a fermentation product. The Epothilone D can be separated from fermentation liquor as long as the molecular imprinting polymer used as sediment is centrifugally separated and collected, then the Epothilone D is extracted from the molecular imprinting polymer, and the molecular imprinting polymer can be reused after being dried.
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