Inventors: Chen DY
Patent Title: Molecularly imprinted polymer for reserpine and preparation method for molecularly imprinted polymer
Publication date: 2012
Publication number: CN102504142

Abstract: The invention discloses molecularly imprinted polymer for reserpine and a preparation method thereof. The preparation method comprises the following steps of: dissolving a functional monomer allyl-beta-cyclodextrin and a template molecule reserpine in dimethylsulfoxide, and mixing at room temperature for 6 to 24 hours; and adding a crosslinking agent ethylene glycol dimethacrylate and an initiator, degassing by using ultrasonic waves, introducing nitrogen to remove oxygen, sealing, performing thermal-initiation polymerization, and cleaning to remove the template molecule. By the molecular recognition capacity of beta-cyclodextrin and the molecular recognition capacity of a molecular imprinting technology, the molecularly imprinted polymer for reserpine is prepared, and a good recognition effect is achieved by optimizing a ratio of various raw materials. The molecular recognition capacity of the beta-cyclodextrin is greatly influenced by modification of the beta-cyclodextrin, so allyl causing small structural change of the beta-cyclodextrin is introduced into a polymerizable unit, the double molecular recognition capacity of the beta-cyclodextrin and the molecular imprinting technology is fully utilized, and the recognition effect is improved.
URL: http://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120620&DB=EPODOC&locale=en_EP&CC=CN&NR=102504142A&KC=A&ND=1