Inventors: Wang JP, Pan MF, Wang S, Fang GZ
Patent Title: Preparation method of methimazole molecularly imprinted polymer
Publication date: 2012
Publication number: CN102336869

Abstract: The invention relates to a preparation method of a methimazole molecularly imprinted polymer. The method comprises the technical key points of: dissolving the template molecule methimazole, the functional monomer methacrylic acid and the cross-linking agent ethylene glycol dimethacrylate in a mole ratio of 1:4:5.81 into the pore forming agent absolute ethanol; adding the initiator azodiisobutyronitrile, conducting ultrasonic processing for 20min, introducing nitrogen for 15min, initiating polymerization under ultraviolet irradiation (lambda=365nm) for 12h; after the reaction, crushing and sieving the product, and taking polymer particles with a particle size of 80-125 micrometers, and washing the particles with a mixed solution of 50mL of methanol and 50mL 1.0mol L<-1> of hydrochloric acid under stirring, carrying out soxhlet extraction with a mixed solution of methanol and glacial acetic acid that are in a volume ratio of 9:1 to remove the template molecule, implementing vacuum drying at a temperature of 70DEG C for 10h, thus obtaining the methimazole molecularly imprinted polymer. The preparation method of the invention has low cost, simple synthesis process and easily controllable reaction conditions, and the obtained molecularly imprinted polymer can be used for concentration of the trace amount of methimazole existing in a sample and substrate purification, so that the method provided in the invention boasts great application value and market prospects.
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