Inventors: Chen XH
, Zhao YG
, Jin MC
Preparation method of magnetic molecularly imprinted composite material of chiral rodenticide bromadiolone
Publication date: 2013
The invention discloses a preparation method of a magnetic molecularly imprinted composite material of chiral rodenticide bromadiolone. The preparation method comprises the following steps of: adding magnetic nanometer ferroferric oxide particle modified via oleic acid to a dispersing agent; adding polymerizing monomer, functional monomer and cross-linking agent; ultrasonically dispersing; adding an initiator; heating; agitating to react to obtain single dispersive polymer composite microsphere rich in epoxy groups; washing until pH (Potential Of Hydrogen) reaches 6 to 8; then drying; adding composite reacting liquid of bromadiolone and an amino functional agent; heating; agitating to react; magnetically separate; washing until the pH reaches 6 to 8; adding organic solvent; ultrasonically eluting to remove template molecule bromadiolone until no bromadiolone an be detected in the eluant through superfast efficient liquid chromatography-tandem mass spectrum; and then drying to obtain a target product. The preparation method disclosed by the invention has the characteristics of being simple in preparation technology, controllable in magnet content, and controllable in ratio of functional group and the like; a product is applicable to enriching, purifying, analyzing and detecting of bromadiolone residual in a biological sample; and the preparation method has a wide application prospect.
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