Inventors: Zhang J, Ma JQ, Wang LL, Tian YL, Wang YL
Patent Title: Preparation method of ofloxacin and 17beta-estradiol double-template molecularly-imprinted composite microsphere
Publication date: 2012
Publication number: CN102718984

Abstract: The invention relates to a preparation method of ofloxacin and 17beta-estradiol double-template molecularly-imprinted composite microspheres, which comprises the following steps of: preparing monodisperse cross-linked epoxypropyl methacrylate microspheres with vinyl bonded on surfaces by using 1, 4-dioxane as a solvent, and preparing the ofloxacin and 17beta-estradiol double-template molecularly-imprinted composite microspheres by using two antibiotics ofloxacin and 17beta-estradiol as templates and by adopting a surface-imprinting technology. The preparation method disclosed by the invention has mild reaction conditions and can be used for preparing the double-template molecularly-imprinted composite microspheres which have better identifying performance for the ofloxacin and the 17beta-estradiol, can be rapidly adsorbed and desorbed and have good stability, so that the simultaneous purification and enrichment of two or more trace components are realized, and references are provided for the simultaneous and rapid detection of multiple medicaments in foods.
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