Inventors: Mi HF, Wang Y, Yang Q
Patent Title: Preparation method and application of molecularly imprinted polymer for directionally protecting functional groups
Publication date: 2012
Publication number: CN102585113

Abstract: The invention provides a preparation method of a molecularly imprinted polymer for directionally protecting functional groups. Two molecularly imprinted polymers are synthesized by using 200-400 meshes of macroporous aminomethyl resin microspheres subjected to double-bond modification as a carrier, methacrylic acid as a monomer, and 2-methyl cyclopentanol as a template or 4-vinyl pyridine as a monomer and 5,6,7,8-tetrahydrogen-2-naphthol as a template. The preparation method has the advantages that: 1) the molecularly imprinted polymer prepared by a surface imprinted technology has the characteristic of specific identification, i.e. selectively adsorbing functional groups requiring for protection; 2) the molecularly imprinted polymer has the function of non-covalent protection to active groups under a same chemical environment, has strong practicality and can be used for protecting functional groups in directional organic chemical reaction, so that the functional groups can be protected effectively and the purity of an objective product reaches 100%; and 3) the prepared molecularly imprinted polymers as the protecting groups can be used repeatedly, and the reaction cost can be reduced, thus the molecularly imprinted polymer is applicable for being popularized in production process.
URL: http://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120718&DB=EPODOC&locale=en_EP&CC=CN&NR=102585113A&KC=A&ND=4