Inventors: Li H
, Wan J
, Gong GL
, Wang XC
Preparation method of epothilone B molecularly imprinted polymer
Publication date: 2012
The invention discloses a preparation method of an epothilone B molecularly imprinted polymer and belongs to the technical field of chemical engineering. The preparation method comprises the following specific steps of: dissolving a template molecule (epothilone B), a functional monomer, a cross-linking agent and an initiator into a pore-foaming agent according to a certain mol ratio, wherein the pore-foaming agent can be a mixed solution of methanol and acetonitrile; after reaction, grinding and sieving the obtained product to obtain particles with the particle size being about 40-60mum; fully washing the obtained particles in a mixed solution of acetic acid and methanol according to the ratio being (1: 9)-(3:7) (v:v) so as to remove the template molecule; and freezing and drying to obtain the epothilone B molecularly imprinted polymer. The epothilone B molecularly imprinted polymer prepared by the preparation method disclosed by the invention can be used for specifically and selectively adsorbing the epothilone B and has greater application value in the production process of the epothilone B by adopting a liquid fermenting method.
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