Inventors: Liu X, Li XX, Huang YP, Liu ZS
Patent Title: Method for preparing molecularly imprinted polymer of levofloxacin through frontal polymerization
Publication date: 2011
Publication number: CN102212160

Abstract: The invention relates to a method for preparing a molecularly imprinted polymer of levofloxacin through frontal polymerization. The method comprises the following steps of: fully and uniformly blending a template molecule, a functional monomer, an active comonomer, a cross-linking agent, an initiator, a foaming agent and a surfactant according to proportions under ultrasonic wave for 3 to 5 hours; pouring the mixed liquid mixture into a cylindrical reactor, and inserting a heated electric iron into the liquid, so that the initiator is heated to be decomposed to ignite the reaction; after the reaction starts, taking out the electric iron, wherein the reaction is kept under the heat released through polymerization and the whole reaction lasts for 1 to 2 hours; and after the reaction, obtaining a yellow polymer, grinding the yellow polymer, performing soxhlet extraction on the powder with methanol/water until the template molecule cannot be detected in the extract, washing the extract with methanol until the extract is neutral, and airing the extract to obtain the molecularly imprinted polymer. The synthetic method is simple, energy-saving, quick in response and high in efficiency; and an organic solvent and post treatment are not required, so the pollution to environment is reduced. Adsorption experiments show that the molecular recognition property of the molecularly imprinted polymer (MIP) is much higher than that of the MIP prepared by the routine bulk polymerization.
URL: http://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20111012&DB=EPODOC&locale=en_EP&CC=CN&NR=102212160A&KC=A&ND=4