Inventors: Wang ZZ
, Gan LS
, Zhou CX
Preparation method and application of molecularly imprinted polymer
Publication date: 2011
The invention provides a method for refining a molecularly imprinted polymer. The method comprises the following steps of: mixing tanshinone IIA serving as a template, a functional monomer, a cross-linking agent, an initiator and a pore-forming agent to prepare a homogeneous system; performing polymerization under the protection of nitrogen; grinding the prepared material into powder and sieving; and soaking, washing and eluting the powder with an alcohol solvent to obtain the molecularly imprinted polymer. The molecularly imprinted polymer prepared by the method represents high affinity and selectivity on the tanshinone IIA in an aqueous mobile phase, serves as a specific separating material and has a wide application prospect on separation, enrichment and purification of the tanshinone IIA in the Chinese medicament. In the method, materials are mixed in one step during synthesis; the preparation process is obviously simplified; time is saved; and an aqueous phase elution system is adopted, so that the application range is enlarged and the elution effect is obvious. The tanshinone IIA provided by the invention can serve as a solid phase extraction material to separate and purify the tanshinone IIA from a salvia miltiorrhiza bunge ethanol crude extract.
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