Inventors: Zhang HX, Yu BF, Zhang JJ, Yang YJ, Zhang KL
Patent Title: Preparation of core-shell ultraviolet fluorescence molecularly-imprinted material and application of material in sulfanilamide detection
Publication date: 2015
Publication number: CN104277190

Abstract: The invention relates to preparation of a core-shell ultraviolet fluorescence molecularly-imprinted material and application of the material in sulfanilamide detection. By using sulfamethyldiazine as a template molecule, the synthesized lysine-based fluorescence molecule as the functional monomer, ethylene glycol dimethyl acrylate as a crosslinking agent and azodiisobutyronitrile as an initiator, the lysine-framework fluorescence functional monomer with FMOC fluorophore is subjected to surface polymerization to obtain an about 10nm imprinted layer on the monodisperse methylacryloylated silicon ball surface with the diameter of 100nm. A Soxhlet method is utilized to remove the imprinted template molecule in the material to obtain the fluorescence molecularly-imprinted sensing material with fluorescence quenching responsiveness to the template molecule; the molecularly-imprinted material has the advantages of favorable dispersity, high response speed and stable optical properties, and is applicable to determining the sulfamethyldiazine content in the marked milk; and the method can indirectly convert the ultraviolet absorption signal of the analyte into a sensitive fluorescence signal, thereby enhancing the detection sensitivity and obtaining favorable recovery rate.
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