Inventors: Ji SL, Ding L, Yang W, Li TF, Li D
Patent Title: Preparation method of hollow porous molecularly imprinted polymer for macrolide antibiotics and application
Publication date: 2018
Publication number: CN107722178A

Abstract: The invention discloses a high-selectivity hollow porous molecularly imprinted polymer for measuring amount of trace macrolide antibiotics residues in animal-derived foods and a preparation method thereof. The preparation method comprises the following steps of using spiramycin as a template molecule, using methacrylic acid as a functional monomer, and using MCM-41 mesoporous silica gel as a sacrifice support template; adopting a thermal induced polymerization method, so as to obtain the hollow porous molecularly imprinted polymer with a memory function on a stereo structure of the macrolide antibiotics. The high-selectivity hollow porous molecularly imprinted polymer is used as a dispersing solid-phase extracting adsorbent, and is used for enriching and selectively separating macrolide antibiotics medicines; by combining with HPLC-MS (high performance liquid chromatography-mass spectrometry)/MS detection, the better effect is obtained. The preparation method is simple. The prepared hollow porous molecularly imprinted material has the advantages that the chemical and mechanical properties and thermal stability are good, the extraction capacity is high, the mass transfer speed is quick, the selectivity is good, the service life is long, and the broad application prospect is realized in the fields of analytical chemistry and environmental analysis.
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