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Reference type: Journal
Authors: Nie F, Lu JR, He YH, Du JX
Article Title: Use of molecule imprinting-chemiluminescence method for the determination of tamoxifen in breast cancer sufferers' urine.
Publication date: 2005
Journal: Luminescence
Volume: 20
Issue: (4-5)
Page numbers: 315-320.
DOI: 10.1002/bio.837

Abstract: The reaction between soluble Mn(IV) and tamoxifen can produce chemiluminescence and formaldehyde can enhance this chemiluminescence reaction. A tamoxifen molecular imprinted polymer (MIP) was synthesized and its adsorption selectivity to tamoxifen in aqueous solution was evaluated. Using a synthesized tamoxifen MIP as the recognition material and a soluble Mn(IV)-formaldehyde-tamoxifen chemiluminesence system as the detection system, a new molecule imprinting-chemiluminesence method of determination of tamoxifen was established. The response range of this method was 1.0 x 10(-7)- 6.0 x 10(-6) g/mL, with a linear correlation coefficient of 0.997. The detection limit was 4 x 10(-8) g/mL. The relative standard deviation for 5.0 x 10(-7) g/mL tamoxifen solution was 4.1% (n = 9). Copyright (c) 2005 John Wiley & Sons, Ltd
Template and target information: tamoxifen
Author keywords: Tamoxifen, Soluble Mn(IV), Molecule imprinting-chemiluminescence method

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