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Reference type: Journal
Authors: Guo PQ, Luo ZM, Xu XY, Zhou YL, Zhang BL, Chang RM, Du W, Chang C, Fu Q
Article Title: Development of molecular imprinted column-on line-two dimensional liquid chromatography for selective determination of clenbuterol residues in biological samples.
Publication date: 2017
Journal: Food Chemistry
Volume: 217
Page numbers: 628-636.
DOI: 10.1016/j.foodchem.2016.09.021
Alternative URL: http://www.sciencedirect.com/science/article/pii/S030881461631408X

Abstract: A novel method coupling molecular imprinted monolithic column with two-dimensional liquid chromatography was developed and validated for the analysis of clenbuterol in pork liver and swine urine samples. The polymers were characterized by using Fourier transform infrared spectroscopy, nitrogen adsorption desorption analyses, frontal analysis and the adsorption of selectivity. The results indicated that the imprinted columns were well prepared and possessed high selectivity adsorption capacity. Subsequently, the MIMC-2D-LC (molecular imprinted monolithic column-two dimensional liquid chromatography) method was developed for the selective analysis of clenbuterol in practical samples. The accuracy ranged from 94.3% to 99.7% and from 93.7% to 99.6% for liver and urine, respectively. The relative standard deviation (RSD) of repeatability was lower than 8.6% for both analyses. The limit of detections was 16 ng mL-1 for liver and 25 ng mL-1 for urine, respectively. Compared with the reported methods, the disturbance of endogenous impurity could be avoided by the 2D-LC method
Template and target information: clenbuterol
Author keywords: clenbuterol, Molecular imprinted monolithic columns, Two-dimensional liquid chromatography, Pork liver, Swine urine


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